A novel role for GSK3β as a modulator of Drosha microprocessor activity and MicroRNA biogenesis

Regulation of microRNA (miR) biogenesis is complex and stringently controlled. Here, we identify the kinase GSK3β as an important modulator of miR biogenesis at Microprocessor level. Repression of GSK3β activity reduces Drosha activity toward pri-miRs, leading to accumulation of unprocessed pri-miRs...

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Detalles Bibliográficos
Autores principales: Fletcher, Claire E., Godfrey, Jack D., Shibakawa, Akifumi, Bushell, Martin, Bevan, Charlotte L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389555/
https://www.ncbi.nlm.nih.gov/pubmed/27907888
http://dx.doi.org/10.1093/nar/gkw938

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389555/
https://www.ncbi.nlm.nih.gov/pubmed/27907888
http://dx.doi.org/10.1093/nar/gkw938

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