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Non-CpG methylation by DNMT3B facilitates REST binding and gene silencing in developing mouse hearts
The dynamic interaction of DNA methylation and transcription factor binding in regulating spatiotemporal gene expression is essential for embryogenesis, but the underlying mechanisms remain understudied. In this study, using mouse models and integration of in vitro and in vivo genetic and epigenetic...
Autores principales: | Zhang, Donghong, Wu, Bingruo, Wang, Ping, Wang, Yidong, Lu, Pengfei, Nechiporuk, Tamilla, Floss, Thomas, Greally, John M., Zheng, Deyou, Zhou, Bin |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Oxford University Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389556/ https://www.ncbi.nlm.nih.gov/pubmed/27956497 http://dx.doi.org/10.1093/nar/gkw1258 |
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