MAX is an epigenetic sensor of 5-carboxylcytosine and is altered in multiple myeloma

The oncogenic transcription factor MYC and its binding partner MAX regulate gene expression by binding to DNA at enhancer-box (E-box) elements 5΄-CACGTG-3΄. In mammalian genomes, the central E-box CpG has the potential to be methylated at the 5-position of cytosine (5mC), or to undergo further oxida...

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Detalles Bibliográficos
Autores principales: Wang, Dongxue, Hashimoto, Hideharu, Zhang, Xing, Barwick, Benjamin G., Lonial, Sagar, Boise, Lawrence H., Vertino, Paula M., Cheng, Xiaodong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389568/
https://www.ncbi.nlm.nih.gov/pubmed/27903915
http://dx.doi.org/10.1093/nar/gkw1184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389568/
https://www.ncbi.nlm.nih.gov/pubmed/27903915
http://dx.doi.org/10.1093/nar/gkw1184

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