Antiviral Activity, Safety, and Pharmacokinetics of Bictegravir as 10-Day Monotherapy in HIV-1–Infected Adults

OBJECTIVE: To evaluate antiviral activity, safety, and pharmacokinetics of short-term monotherapy with bictegravir (BIC), a novel, potent HIV integrase strand transfer inhibitor (INSTI). DESIGN: Phase 1b, randomized, double-blinded, adaptive, sequential cohort, placebo-controlled study. METHODS: HIV...

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Detalles Bibliográficos
Autores principales: Gallant, Joel E., Thompson, Melanie, DeJesus, Edwin, Voskuhl, Gene W., Wei, Xuelian, Zhang, Heather, White, Kirsten, Cheng, Andrew, Quirk, Erin, Martin, Hal
Formato: Online Artículo Texto
Lenguaje:English
Publicado: JAIDS Journal of Acquired Immune Deficiency Syndromes 2017
Materias:
Clinical Science
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389589/
https://www.ncbi.nlm.nih.gov/pubmed/28196003
http://dx.doi.org/10.1097/QAI.0000000000001306

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389589/
https://www.ncbi.nlm.nih.gov/pubmed/28196003
http://dx.doi.org/10.1097/QAI.0000000000001306

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