DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA

Mutations in SPARTAN are associated with early onset hepatocellular carcinoma and progeroid features. A regulatory function of Spartan has been implicated in DNA damage tolerance pathways such as translesion synthesis, but the exact function of the protein remained unclear. Here, we reveal the role...

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Detalles Bibliográficos
Autores principales: Mórocz, Mónika, Zsigmond, Eszter, Tóth, Róbert, Enyedi, Márton Zs, Pintér, Lajos, Haracska, Lajos
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389635/
https://www.ncbi.nlm.nih.gov/pubmed/28053116
http://dx.doi.org/10.1093/nar/gkw1315

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389635/
https://www.ncbi.nlm.nih.gov/pubmed/28053116
http://dx.doi.org/10.1093/nar/gkw1315

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