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DNA-dependent protease activity of human Spartan facilitates replication of DNA–protein crosslink-containing DNA
Mutations in SPARTAN are associated with early onset hepatocellular carcinoma and progeroid features. A regulatory function of Spartan has been implicated in DNA damage tolerance pathways such as translesion synthesis, but the exact function of the protein remained unclear. Here, we reveal the role...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Oxford University Press
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389635/ https://www.ncbi.nlm.nih.gov/pubmed/28053116 http://dx.doi.org/10.1093/nar/gkw1315 |