ING1 regulates rRNA levels by altering nucleolar chromatin structure and mTOR localization

Epigenetic, transcriptional and signaling processes in the nucleolus regulate rRNA transcription and cell growth. We report here that the tumor suppressor ING1b binds rDNA, regulates rDNA chromatin modifications and affects nucleolar localization of mTOR to modulate rRNA levels. ING1 represses rDNA...

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Detalles Bibliográficos
Autores principales: Rajarajacholan, Uma Karthika, Thalappilly, Subhash, Riabowol, Karl
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389678/
https://www.ncbi.nlm.nih.gov/pubmed/27903908
http://dx.doi.org/10.1093/nar/gkw1161

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389678/
https://www.ncbi.nlm.nih.gov/pubmed/27903908
http://dx.doi.org/10.1093/nar/gkw1161

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