In vivo modification of tRNA with an artificial nucleobase leads to full disease remission in an animal model of multiple sclerosis

Queuine is a modified pyrrolopyrimidine nucleobase derived exclusively from bacteria. It post-transcriptionally replaces guanine 34 in transfer RNA isoacceptors for Asp, Asn, His and Tyr, in almost all eukaryotic organisms, through the activity of the ancient tRNA guanine transglycosylase (TGT) enzy...

Descripción completa

Detalles Bibliográficos
Autores principales: Varghese, Sreeja, Cotter, Michelle, Chevot, Franciane, Fergus, Claire, Cunningham, Colm, Mills, Kingston H., Connon, Stephen J., Southern, John M., Kelly, Vincent P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2017
Materias:
RNA
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389723/
https://www.ncbi.nlm.nih.gov/pubmed/28204548
http://dx.doi.org/10.1093/nar/gkw847

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389723/
https://www.ncbi.nlm.nih.gov/pubmed/28204548
http://dx.doi.org/10.1093/nar/gkw847

Ejemplares similares