Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells

Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca(2+) influx, which is modulated by the two-pore-domain K(+) (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 diabetes. While TALK-1 serves an important role...

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Detalles Bibliográficos
Autores principales: Dickerson, Matthew T., Vierra, Nicholas C., Milian, Sarah C., Dadi, Prasanna K., Jacobson, David A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389796/
https://www.ncbi.nlm.nih.gov/pubmed/28403169
http://dx.doi.org/10.1371/journal.pone.0175069

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389796/
https://www.ncbi.nlm.nih.gov/pubmed/28403169
http://dx.doi.org/10.1371/journal.pone.0175069

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