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Osteopontin activates the diabetes-associated potassium channel TALK-1 in pancreatic β-cells
Glucose-stimulated insulin secretion (GSIS) relies on β-cell Ca(2+) influx, which is modulated by the two-pore-domain K(+) (K2P) channel, TALK-1. A gain-of-function polymorphism in KCNK16, the gene encoding TALK-1, increases risk for developing type-2 diabetes. While TALK-1 serves an important role...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389796/ https://www.ncbi.nlm.nih.gov/pubmed/28403169 http://dx.doi.org/10.1371/journal.pone.0175069 |