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Vascular endothelial growth factor A amplification in colorectal cancer is associated with reduced M1 and M2 macrophages and diminished PD-1-expressing lymphocytes
VEGFA is an angiogenic factor secreted by tumors, in particular those with VEGFA amplification, as well as by macrophages and lymphocytes in the tumor microenvironment. Here we sought to define the presence of M1/M2 macrophages, PD-1-positive lymphocytes and PD-L1 tumoral and stromal expression in c...
Autores principales: | Burmeister, Katharina, Quagliata, Luca, Andreozzi, Mariacarla, Eppenberger-Castori, Serenella, Matter, Matthias S., Perrina, Valeria, Grobholz, Rainer, Jochum, Wolfram, Horber, Daniel, Moosmann, Peter, Lehmann, Frank, Köberle, Dieter, Ng, Charlotte K. Y., Piscuoglio, Salvatore, Tornillo, Luigi, Terracciano, Luigi M. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5389821/ https://www.ncbi.nlm.nih.gov/pubmed/28403223 http://dx.doi.org/10.1371/journal.pone.0175563 |
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