The hot-spot p53R172H mutant promotes formation of giant spermatogonia triggered by DNA damage

Overexpression of mutant p53 is a common finding in most cancers but testicular tumours accumulate wild-type p53 (wtp53). In contrast to the accepted concept that p53 homozygous mutant mice do not accumulate mutant p53 in normal cells, our study on a mutant p53 mouse model of Li-Fraumeni syndrome ha...

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Detalles Bibliográficos
Autores principales: Xue, Y, Raharja, A, Sim, W, Wong, E S M, Rahmat, S A B, Lane, D P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390101/
https://www.ncbi.nlm.nih.gov/pubmed/27869164
http://dx.doi.org/10.1038/onc.2016.374

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390101/
https://www.ncbi.nlm.nih.gov/pubmed/27869164
http://dx.doi.org/10.1038/onc.2016.374

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