Knockdown of stem cell regulator Oct4A in ovarian cancer reveals cellular reprogramming associated with key regulators of cytoskeleton-extracellular matrix remodelling

Oct4A is a master regulator of self-renewal and pluripotency in embryonic stem cells. It is a well-established marker for cancer stem cell (CSC) in malignancies. Recently, using a loss of function studies, we have demonstrated key roles for Oct4A in tumor cell survival, metastasis and chemoresistanc...

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Detalles Bibliográficos
Autores principales: Samardzija, Chantel, Greening, David W., Escalona, Ruth, Chen, Maoshan, Bilandzic, Maree, Luwor, Rodney, Kannourakis, George, Findlay, Jock K., Ahmed, Nuzhat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390261/
https://www.ncbi.nlm.nih.gov/pubmed/28406185
http://dx.doi.org/10.1038/srep46312

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390261/
https://www.ncbi.nlm.nih.gov/pubmed/28406185
http://dx.doi.org/10.1038/srep46312

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