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High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss

Dopamine plays an important role in goal-directed behavior, through its modulatory influence on striatal neurons. It is unclear whether tonic dopamine levels, which regulate the vigor of acting, interact with the phasic dopamine response to reward that drives instrumental behavior. In a randomized p...

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Detalles Bibliográficos
Autores principales: Evers, E.A., Stiers, P., Ramaekers, J.G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390715/
https://www.ncbi.nlm.nih.gov/pubmed/27677943
http://dx.doi.org/10.1093/scan/nsw124
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author Evers, E.A.
Stiers, P.
Ramaekers, J.G.
author_facet Evers, E.A.
Stiers, P.
Ramaekers, J.G.
author_sort Evers, E.A.
collection PubMed
description Dopamine plays an important role in goal-directed behavior, through its modulatory influence on striatal neurons. It is unclear whether tonic dopamine levels, which regulate the vigor of acting, interact with the phasic dopamine response to reward that drives instrumental behavior. In a randomized placebo-controlled study in healthy volunteers, we show that methylphenidate, a drug that increases tonic dopamine levels, systematically reduced striatal phasic BOLD responses to gain and loss in a gambling task as measured with fMRI. It also increased response vigor and reward expectancy-related BOLD signals in the ventral striatum. These findings suggest that striatal tonic dopamine levels constitute an average reward expectation signal that modulates the phasic dopaminergic response to reward. This offers opportunities for treatment of behavioral disorders associated with abnormal reward sensitivity.
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spelling pubmed-53907152017-05-01 High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss Evers, E.A. Stiers, P. Ramaekers, J.G. Soc Cogn Affect Neurosci Original Articles Dopamine plays an important role in goal-directed behavior, through its modulatory influence on striatal neurons. It is unclear whether tonic dopamine levels, which regulate the vigor of acting, interact with the phasic dopamine response to reward that drives instrumental behavior. In a randomized placebo-controlled study in healthy volunteers, we show that methylphenidate, a drug that increases tonic dopamine levels, systematically reduced striatal phasic BOLD responses to gain and loss in a gambling task as measured with fMRI. It also increased response vigor and reward expectancy-related BOLD signals in the ventral striatum. These findings suggest that striatal tonic dopamine levels constitute an average reward expectation signal that modulates the phasic dopaminergic response to reward. This offers opportunities for treatment of behavioral disorders associated with abnormal reward sensitivity. Oxford University Press 2016-09-27 /pmc/articles/PMC5390715/ /pubmed/27677943 http://dx.doi.org/10.1093/scan/nsw124 Text en © The Author(s) (2016). Published by Oxford University Press. http://creativecommons.org/licenses/by-nc/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits non-commercial re-use, distribution, and reproduction in any medium, provided the original work is properly cited. For commercial re-use, please contact journals.permissions@oup.com
spellingShingle Original Articles
Evers, E.A.
Stiers, P.
Ramaekers, J.G.
High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title_full High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title_fullStr High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title_full_unstemmed High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title_short High reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
title_sort high reward expectancy during methylphenidate depresses the dopaminergic response to gain and loss
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390715/
https://www.ncbi.nlm.nih.gov/pubmed/27677943
http://dx.doi.org/10.1093/scan/nsw124
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