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Fluorogenic sensor platform for the histone code using receptors from dynamic combinatorial libraries

Post-translational modifications (PTMs) on histone tails act in diverse combinations in the ‘histone code’ to control gene expression, with dysregulation observed in a variety of diseases. However, detection and sensing methods are limited, expensive, and/or low-throughput, including MS and antibody...

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Detalles Bibliográficos
Autores principales: Peacor, Brendan C., Ramsay, Christopher M., Waters, Marcey L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390788/
https://www.ncbi.nlm.nih.gov/pubmed/28451282
http://dx.doi.org/10.1039/c6sc03003c