De Novo Modular Development of a Foldameric Protein–Protein Interaction Inhibitor for Separate Hot Spots: A Dynamic Covalent Assembly Approach

Protein–protein interactions stabilized by multiple separate hot spots are highly challenging targets for synthetic scaffolds. Surface‐mimetic foldamers bearing multiple recognition segments are promising candidate inhibitors. In this work, a modular bottom‐up approach is implemented by identifying...

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Detalles Bibliográficos
Autores principales: Bartus, Éva, Hegedüs, Zsófia, Wéber, Edit, Csipak, Brigitta, Szakonyi, Gerda, Martinek, Tamás A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Communications
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390796/
https://www.ncbi.nlm.nih.gov/pubmed/28413758
http://dx.doi.org/10.1002/open.201700012

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390796/
https://www.ncbi.nlm.nih.gov/pubmed/28413758
http://dx.doi.org/10.1002/open.201700012

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