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Influence of drug transporters and stereoselectivity on the brain penetration of pioglitazone as a potential medicine against Alzheimer's disease

Pioglitazone is currently undergoing clinical trials for treatment of Alzheimer's disease (AD). However, poor brain penetration remains an obstacle to development of the drug for such intended clinical uses. In this study, we demonstrate that the inhibition of P-glycoprotein (P-gp) significantl...

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Detalles Bibliográficos
Autores principales: Chang, Kai Lun, Pee, Hai Ning, Yang, Shili, Ho, Paul C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390903/
https://www.ncbi.nlm.nih.gov/pubmed/25760794
http://dx.doi.org/10.1038/srep09000