Amide-controlled, one-pot synthesis of tri-substituted purines generates structural diversity and analogues with trypanocidal activity

A novel one-pot synthesis of tri-substituted purines and the discovery of purine analogues with trypanocidal activity are reported. The reaction is initiated by a metal-free oxidative coupling of primary alkoxides and diaminopyrimidines with Schiff base formation and subsequent annulation in the pre...

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Detalles Bibliográficos
Autores principales: Pineda de las Infantas y Villatoro, Maria J., Unciti-Broceta, Juan D., Contreras-Montoya, Rafael, Garcia-Salcedo, Jose A., Gallo Mezo, Miguel A., Unciti-Broceta, Asier, Diaz-Mochon, Juan J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390905/
https://www.ncbi.nlm.nih.gov/pubmed/25773920
http://dx.doi.org/10.1038/srep09139

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390905/
https://www.ncbi.nlm.nih.gov/pubmed/25773920
http://dx.doi.org/10.1038/srep09139

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