Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial

Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary...

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Autores principales: Verheyen, Nicolas, Fahrleitner-Pammer, Astrid, Belyavskiy, Evgeny, Gruebler, Martin R., Dimai, Hans Peter, Amrein, Karin, Ablasser, Klemens, Martensen, Johann, Catena, Cristiana, Pieske-Kraigher, Elisabeth, Colantonio, Caterina, Voelkl, Jakob, Lang, Florian, Alesutan, Ioana, Meinitzer, Andreas, März, Winfried, Brussee, Helmut, Pieske, Burkert, Pilz, Stefan, Tomaschitz, Andreas
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390970/
https://www.ncbi.nlm.nih.gov/pubmed/28406904
http://dx.doi.org/10.1371/journal.pone.0173799
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author Verheyen, Nicolas
Fahrleitner-Pammer, Astrid
Belyavskiy, Evgeny
Gruebler, Martin R.
Dimai, Hans Peter
Amrein, Karin
Ablasser, Klemens
Martensen, Johann
Catena, Cristiana
Pieske-Kraigher, Elisabeth
Colantonio, Caterina
Voelkl, Jakob
Lang, Florian
Alesutan, Ioana
Meinitzer, Andreas
März, Winfried
Brussee, Helmut
Pieske, Burkert
Pilz, Stefan
Tomaschitz, Andreas
author_facet Verheyen, Nicolas
Fahrleitner-Pammer, Astrid
Belyavskiy, Evgeny
Gruebler, Martin R.
Dimai, Hans Peter
Amrein, Karin
Ablasser, Klemens
Martensen, Johann
Catena, Cristiana
Pieske-Kraigher, Elisabeth
Colantonio, Caterina
Voelkl, Jakob
Lang, Florian
Alesutan, Ioana
Meinitzer, Andreas
März, Winfried
Brussee, Helmut
Pieske, Burkert
Pilz, Stefan
Tomaschitz, Andreas
author_sort Verheyen, Nicolas
collection PubMed
description Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary hyperparathyroidism (pHPT). Cross-sectional data of 155 subjects with pHPT were analyzed who participated in the “Eplerenone in Primary Hyperparathyroidism” (EPATH) Trial. Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e’, diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed. Analyses were additionally adjusted for plasma parathyroid hormone, plasma calcium, age, sex, HbA1c, body mass index, mean 24-hours systolic blood pressure, smoking status, estimated glomerular filtration rate, antihypertensive treatment, osteoporosis treatment, 25-hydroxy vitamin D and N-terminal pro-brain B-type natriuretic peptide. Independent relationships were observed between P1NP and LVEF (adjusted β-coefficient = 0.201, P = 0.035) and e’ (β = 0.188, P = 0.042), respectively. OC (β = 0.192, P = 0.039) and BALP (β = 0.198, P = 0.030) were each independently related with e’. CTX showed no correlations with LVEF or e’. In conclusion, high bone formation markers were independently and paradoxically related with better LV diastolic and, partly, better systolic function, in the setting of pHPT. Potentially cardio-protective properties of stimulated bone formation in the context of hyperparathyroidism should be explored in future studies.
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spelling pubmed-53909702017-05-03 Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial Verheyen, Nicolas Fahrleitner-Pammer, Astrid Belyavskiy, Evgeny Gruebler, Martin R. Dimai, Hans Peter Amrein, Karin Ablasser, Klemens Martensen, Johann Catena, Cristiana Pieske-Kraigher, Elisabeth Colantonio, Caterina Voelkl, Jakob Lang, Florian Alesutan, Ioana Meinitzer, Andreas März, Winfried Brussee, Helmut Pieske, Burkert Pilz, Stefan Tomaschitz, Andreas PLoS One Research Article Observational studies suggested a link between bone disease and left ventricular (LV) dysfunction that may be pronounced in hyperparathyroid conditions. We therefore aimed to test the hypothesis that circulating markers of bone turnover correlate with LV function in a cohort of patients with primary hyperparathyroidism (pHPT). Cross-sectional data of 155 subjects with pHPT were analyzed who participated in the “Eplerenone in Primary Hyperparathyroidism” (EPATH) Trial. Multivariate linear regression analyses with LV ejection fraction (LVEF, systolic function) or peak early transmitral filling velocity (e’, diastolic function) as dependent variables and N-terminal propeptide of procollagen type 1 (P1NP), osteocalcin (OC), bone-specific alkaline phosphatase (BALP), or beta-crosslaps (CTX) as the respective independent variable were performed. Analyses were additionally adjusted for plasma parathyroid hormone, plasma calcium, age, sex, HbA1c, body mass index, mean 24-hours systolic blood pressure, smoking status, estimated glomerular filtration rate, antihypertensive treatment, osteoporosis treatment, 25-hydroxy vitamin D and N-terminal pro-brain B-type natriuretic peptide. Independent relationships were observed between P1NP and LVEF (adjusted β-coefficient = 0.201, P = 0.035) and e’ (β = 0.188, P = 0.042), respectively. OC (β = 0.192, P = 0.039) and BALP (β = 0.198, P = 0.030) were each independently related with e’. CTX showed no correlations with LVEF or e’. In conclusion, high bone formation markers were independently and paradoxically related with better LV diastolic and, partly, better systolic function, in the setting of pHPT. Potentially cardio-protective properties of stimulated bone formation in the context of hyperparathyroidism should be explored in future studies. Public Library of Science 2017-04-13 /pmc/articles/PMC5390970/ /pubmed/28406904 http://dx.doi.org/10.1371/journal.pone.0173799 Text en © 2017 Verheyen et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Verheyen, Nicolas
Fahrleitner-Pammer, Astrid
Belyavskiy, Evgeny
Gruebler, Martin R.
Dimai, Hans Peter
Amrein, Karin
Ablasser, Klemens
Martensen, Johann
Catena, Cristiana
Pieske-Kraigher, Elisabeth
Colantonio, Caterina
Voelkl, Jakob
Lang, Florian
Alesutan, Ioana
Meinitzer, Andreas
März, Winfried
Brussee, Helmut
Pieske, Burkert
Pilz, Stefan
Tomaschitz, Andreas
Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title_full Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title_fullStr Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title_full_unstemmed Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title_short Relationship between bone turnover and left ventricular function in primary hyperparathyroidism: The EPATH trial
title_sort relationship between bone turnover and left ventricular function in primary hyperparathyroidism: the epath trial
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5390970/
https://www.ncbi.nlm.nih.gov/pubmed/28406904
http://dx.doi.org/10.1371/journal.pone.0173799
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