C1q ablation exacerbates amyloid deposition: A study in a transgenic mouse model of ATTRV30M amyloid neuropathy

ATTRV30M amyloid neuropathy is a lethal autosomal dominant sensorimotor and autonomic neuropathy, caused by deposition of amyloid fibrils composed of aberrant transthyretin (TTR). Ages of onset and penetrance exhibit great variability and genetic factors have been implicated. Complement activation c...

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Detalles Bibliográficos
Autores principales: Panayiotou, Elena, Fella, Eleni, Papacharalambous, Revekka, Malas, Stavros, Saraiva, Maria Joao, Kyriakides, Theodoros
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391113/
https://www.ncbi.nlm.nih.gov/pubmed/28407005
http://dx.doi.org/10.1371/journal.pone.0175767

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391113/
https://www.ncbi.nlm.nih.gov/pubmed/28407005
http://dx.doi.org/10.1371/journal.pone.0175767

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