Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4

The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response. We find that ataxin‐3 negatively regulates ubiquitylatio...

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Detalles Bibliográficos
Autores principales: Pfeiffer, Annika, Luijsterburg, Martijn S, Acs, Klara, Wiegant, Wouter W, Helfricht, Angela, Herzog, Laura K, Minoia, Melania, Böttcher, Claudia, Salomons, Florian A, van Attikum, Haico, Dantuma, Nico P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391139/
https://www.ncbi.nlm.nih.gov/pubmed/28275011
http://dx.doi.org/10.15252/embj.201695151

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391139/
https://www.ncbi.nlm.nih.gov/pubmed/28275011
http://dx.doi.org/10.15252/embj.201695151

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