Cargando…

Ataxin‐3 consolidates the MDC1‐dependent DNA double‐strand break response by counteracting the SUMO‐targeted ubiquitin ligase RNF4

The SUMO‐targeted ubiquitin ligase RNF4 functions at the crossroads of the SUMO and ubiquitin systems. Here, we report that the deubiquitylation enzyme (DUB) ataxin‐3 counteracts RNF4 activity during the DNA double‐strand break (DSB) response. We find that ataxin‐3 negatively regulates ubiquitylatio...

Descripción completa

Detalles Bibliográficos
Autores principales:	Pfeiffer, Annika, Luijsterburg, Martijn S, Acs, Klara, Wiegant, Wouter W, Helfricht, Angela, Herzog, Laura K, Minoia, Melania, Böttcher, Claudia, Salomons, Florian A, van Attikum, Haico, Dantuma, Nico P
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	John Wiley and Sons Inc. 2017
Materias:	Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391139/ https://www.ncbi.nlm.nih.gov/pubmed/28275011 http://dx.doi.org/10.15252/embj.201695151

Ejemplares similares

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80
por: Typas, Dimitris, et al.
Publicado: (2015)

The de-ubiquitylating enzymes USP26 and USP37 regulate homologous recombination by counteracting RAP80
por: Typas, Dimitris, et al.
Publicado: (2016)

Remodeling and spacing factor 1 (RSF1) deposits centromere proteins at DNA double-strand breaks to promote non-homologous end-joining
por: Helfricht, Angela, et al.
Publicado: (2013)

DDB2 promotes chromatin decondensation at UV-induced DNA damage
por: Luijsterburg, Martijn S., et al.
Publicado: (2012)

Antisense oligonucleotide-mediated exon skipping as a strategy to reduce proteolytic cleavage of ataxin-3
por: Toonen, Lodewijk J. A., et al.
Publicado: (2016)

A PALB2-interacting domain in RNF168 couples homologous recombination to DNA break-induced chromatin ubiquitylation
por: Luijsterburg, Martijn S, et al.
Publicado: (2017)

SUMOylation by SUMO2 is implicated in the degradation of misfolded ataxin-7 via RNF4 in SCA7 models
por: Marinello, Martina, et al.
Publicado: (2019)

The Machado–Joseph disease deubiquitylase ataxin‐3 interacts with LC3C/GABARAP and promotes autophagy
por: Herzog, Laura K., et al.
Publicado: (2019)

WWP2 ubiquitylates RNA polymerase II for DNA-PK-dependent transcription arrest and repair at DNA breaks
por: Caron, Pierre, et al.
Publicado: (2019)

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response
por: Marteijn, Jurgen A., et al.
Publicado: (2009)

Autophagy mediates SUMO-induced degradation of a polyglutamine protein ataxin-3
por: Hwang, Soo Pyung, et al.
Publicado: (2017)

SUMO Chain-Induced Dimerization Activates RNF4
por: Rojas-Fernandez, Alejandro, et al.
Publicado: (2014)

The NuRD chromatin–remodeling complex regulates signaling and repair of DNA damage
por: Smeenk, Godelieve, et al.
Publicado: (2010)

SUMOylation and PARylation cooperate to recruit and stabilize SLX4 at DNA damage sites
por: González-Prieto, Román, et al.
Publicado: (2015)

Arkadia/RNF111 is a SUMO-targeted ubiquitin ligase with preference for substrates marked with SUMO1-capped SUMO2/3 chain
por: Sriramachandran, Annie M., et al.
Publicado: (2019)

Arsenic-Induced SUMO-Dependent Recruitment of RNF4 into PML Nuclear Bodies
por: Geoffroy, Marie-Claude, et al.
Publicado: (2010)

Structural insight into SUMO chain recognition and manipulation by the ubiquitin ligase RNF4
por: Xu, Yingqi, et al.
Publicado: (2014)

CHD7 and 53BP1 regulate distinct pathways for the re-ligation of DNA double-strand breaks
por: Rother, Magdalena B., et al.
Publicado: (2020)

SIRT3 consolidates heterochromatin and counteracts senescence
por: Diao, Zhiqing, et al.
Publicado: (2021)

PARP1 Links CHD2-Mediated Chromatin Expansion and H3.3 Deposition to DNA Repair by Non-homologous End-Joining
por: Luijsterburg, Martijn S., et al.
Publicado: (2016)

C-terminal UBA domains protect ubiquitin receptors by preventing initiation of protein degradation
por: Heinen, Christian, et al.
Publicado: (2011)

The p97–Ataxin 3 complex regulates homeostasis of the DNA damage response E3 ubiquitin ligase RNF8
por: Singh, Abhay Narayan, et al.
Publicado: (2019)

Real Estate in the DNA Damage Response: Ubiquitin and SUMO Ligases Home in on DNA Double-Strand Breaks
por: Dantuma, Nico P., et al.
Publicado: (2016)

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response
por: Poulsen, Sara L., et al.
Publicado: (2013)

The STUbL RNF4 regulates protein group SUMOylation by targeting the SUMO conjugation machinery
por: Kumar, Ramesh, et al.
Publicado: (2017)

Correction to ‘SIRT3 consolidates heterochromatin and counteracts senescence’
por: Diao, Zhiqing, et al.
Publicado: (2021)

SUMO-1 Modification on K166 of PolyQ-Expanded aTaxin-3 Strengthens Its Stability and Increases Its Cytotoxicity
por: Zhou, Ya-Fang, et al.
Publicado: (2013)

MDC-13 Kangaroo mothers in Colombia
por: Charpak, Georges
Publicado: (1999)

DNA repair goes hip-hop: SMARCA and CHD chromatin remodellers join the break dance
por: Rother, Magdalena B., et al.
Publicado: (2017)

RNF4 and VHL regulate the proteasomal degradation of SUMO-conjugated Hypoxia-Inducible Factor-2α
por: van Hagen, Martijn, et al.
Publicado: (2010)

The SUMO-targeted ubiquitin ligase RNF4 regulates localization and function of the HTLV-1 oncoprotein Tax
por: Fryrear, Kimberly A, et al.
Publicado: (2011)

Antagonistic roles of ubiquitin ligase HEI10 and SUMO ligase RNF212 regulate meiotic recombination
por: Qiao, Huanyu, et al.
Publicado: (2014)

Circular RNA circRNF13 inhibits proliferation and metastasis of nasopharyngeal carcinoma via SUMO2
por: Mo, Yongzhen, et al.
Publicado: (2021)

Genomic Reporter Constructs to Monitor Pathway-Specific Repair of DNA Double-Strand Breaks
por: van de Kooij, Bert, et al.
Publicado: (2022)

Ubiquitin versus misfolding: The minimal requirements for inclusion body formation
por: Dantuma, Nico P., et al.
Publicado: (2016)

Requirement of PML SUMO Interacting Motif for RNF4- or Arsenic Trioxide-Induced Degradation of Nuclear PML Isoforms
por: Maroui, Mohamed Ali, et al.
Publicado: (2012)

Mechanism and function of DNA replication‐independent DNA‐protein crosslink repair via the SUMO‐RNF4 pathway
por: Liu, Julio C Y, et al.
Publicado: (2021)

FOX-2 Dependent Splicing of Ataxin-2 Transcript Is Affected by Ataxin-1 Overexpression
por: Welzel, Franziska, et al.
Publicado: (2012)

Opposing ISWI- and CHD-class chromatin remodeling activities orchestrate heterochromatic DNA repair
por: Klement, Karolin, et al.
Publicado: (2014)

The yeast Fun30 and human SMARCAD1 chromatin remodelers promote DNA end resection
por: Costelloe, Thomas, et al.
Publicado: (2012)

Cannot write session to /tmp/vufind_sessions/sess_b6nqqmvek0i2v8rsjokil6tiu5