Structural basis for halogenation by iron- and 2-oxo-glutarate-dependent enzyme WelO5

A 2.4-Å-resolution x-ray crystal structure of the carrier-protein independent halogenase, WelO5, in complex with its welwitindolinone precursor substrate, 12-epi-fischerindole U, reveals that the C13 chlorination target is proximal to the anticipated site of the oxo group in a presumptive cis-halo-o...

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Detalles Bibliográficos
Autores principales: Mitchell, Andrew J., Zhu, Qin, Maggiolo, Ailiena O., Ananth, Nikhil, Hillwig, Matthew L., Liu, Xinyu, Boal, Amie K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391150/
https://www.ncbi.nlm.nih.gov/pubmed/27348090
http://dx.doi.org/10.1038/nchembio.2112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391150/
https://www.ncbi.nlm.nih.gov/pubmed/27348090
http://dx.doi.org/10.1038/nchembio.2112

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