The PERK arm of the unfolded protein response regulates satellite cell-mediated skeletal muscle regeneration

Regeneration of skeletal muscle in adults is mediated by satellite stem cells. Accumulation of misfolded proteins triggers endoplasmic reticulum stress that leads to unfolded protein response (UPR). The UPR is relayed to the cell through the activation of PERK, IRE1/XBP1, and ATF6. Here, we demonstr...

Descripción completa

Detalles Bibliográficos
Autores principales: Xiong, Guangyan, Hindi, Sajedah M, Mann, Aman K, Gallot, Yann S, Bohnert, Kyle R, Cavener, Douglas R, Whittemore, Scott R, Kumar, Ashok
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Cell Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391206/
https://www.ncbi.nlm.nih.gov/pubmed/28332979
http://dx.doi.org/10.7554/eLife.22871

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391206/
https://www.ncbi.nlm.nih.gov/pubmed/28332979
http://dx.doi.org/10.7554/eLife.22871

Ejemplares similares