New agents that target senescent cells: the flavone, fisetin, and the BCL-X(L) inhibitors, A1331852 and A1155463

Senescent cells accumulate with aging and at sites of pathology in multiple chronic diseases. Senolytics are drugs that selectively promote apoptosis of senescent cells by temporarily disabling the pro-survival pathways that enable senescent cells to resist the pro-apoptotic, pro-inflammatory factor...

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Detalles Bibliográficos
Autores principales: Zhu, Yi, Doornebal, Ewald J., Pirtskhalava, Tamar, Giorgadze, Nino, Wentworth, Mark, Fuhrmann-Stroissnigg, Heike, Niedernhofer, Laura J., Robbins, Paul D., Tchkonia, Tamara, Kirkland, James L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391241/
https://www.ncbi.nlm.nih.gov/pubmed/28273655
http://dx.doi.org/10.18632/aging.101202

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391241/
https://www.ncbi.nlm.nih.gov/pubmed/28273655
http://dx.doi.org/10.18632/aging.101202

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