Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids

The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole/fischerindole type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug developme...

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Autores principales: Li, Shasha, Lowell, Andrew N., Newmister, Sean A., Yu, Fengan, Williams, Robert M., Sherman, David H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391265/
https://www.ncbi.nlm.nih.gov/pubmed/28288107
http://dx.doi.org/10.1038/nchembio.2327
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author Li, Shasha
Lowell, Andrew N.
Newmister, Sean A.
Yu, Fengan
Williams, Robert M.
Sherman, David H.
author_facet Li, Shasha
Lowell, Andrew N.
Newmister, Sean A.
Yu, Fengan
Williams, Robert M.
Sherman, David H.
author_sort Li, Shasha
collection PubMed
description The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole/fischerindole type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade.
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spelling pubmed-53912652017-09-13 Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids Li, Shasha Lowell, Andrew N. Newmister, Sean A. Yu, Fengan Williams, Robert M. Sherman, David H. Nat Chem Biol Article The formation of C-C bonds in an enantioselective fashion to create complex polycyclic scaffolds in the hapalindole/fischerindole type alkaloids from Stigonematales cyanobacteria represents a compelling and urgent challenge in adapting microbial biosynthesis as a catalytic platform in drug development. Here we determine the biochemical basis for tri- and tetracyclic core formation in these secondary metabolites, involving a new class of cyclases that catalyze a complex cyclization cascade. 2017-03-13 2017-05 /pmc/articles/PMC5391265/ /pubmed/28288107 http://dx.doi.org/10.1038/nchembio.2327 Text en Users may view, print, copy, and download text and data-mine the content in such documents, for the purposes of academic research, subject always to the full Conditions of use: http://www.nature.com/authors/editorial_policies/license.html#terms
spellingShingle Article
Li, Shasha
Lowell, Andrew N.
Newmister, Sean A.
Yu, Fengan
Williams, Robert M.
Sherman, David H.
Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title_full Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title_fullStr Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title_full_unstemmed Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title_short Decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
title_sort decoding cyclase-dependent assembly of hapalindole and fischerindole alkaloids
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391265/
https://www.ncbi.nlm.nih.gov/pubmed/28288107
http://dx.doi.org/10.1038/nchembio.2327
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