Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines

The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 has three key tyrosines (Tyr-113, Tyr-128, and Tyr-1...

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Detalles Bibliográficos
Autores principales: Thaker, Youg R., Recino, Asha, Raab, Monika, Jabeen, Asma, Wallberg, Maja, Fernandez, Nelson, Rudd, Christopher E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2017
Materias:
Signal Transduction
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391757/
https://www.ncbi.nlm.nih.gov/pubmed/28188290
http://dx.doi.org/10.1074/jbc.M116.759555

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391757/
https://www.ncbi.nlm.nih.gov/pubmed/28188290
http://dx.doi.org/10.1074/jbc.M116.759555

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