Cargando…
Activated Cdc42-associated kinase 1 (ACK1) binds the sterile α motif (SAM) domain of the adaptor SLP-76 and phosphorylates proximal tyrosines
The adaptor protein Src homology 2 domain-containing leukocyte phosphoprotein of 76 kDa (SLP-76) plays a crucial role in T cell activation by linking antigen receptor (T cell receptor, TCR) signals to downstream pathways. At its N terminus, SLP-76 has three key tyrosines (Tyr-113, Tyr-128, and Tyr-1...
Autores principales: | Thaker, Youg R., Recino, Asha, Raab, Monika, Jabeen, Asma, Wallberg, Maja, Fernandez, Nelson, Rudd, Christopher E. |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Society for Biochemistry and Molecular Biology
2017
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391757/ https://www.ncbi.nlm.nih.gov/pubmed/28188290 http://dx.doi.org/10.1074/jbc.M116.759555 |
Ejemplares similares
-
SLP-76 Sterile α Motif (SAM) and Individual H5 α Helix Mediate Oligomer Formation for Microclusters and T-cell Activation
por: Liu, Hebin, et al.
Publicado: (2013) -
A dock and coalesce mechanism driven by hydrophobic interactions governs Cdc42 binding with its effector protein ACK
por: Tetley, George J. N., et al.
Publicado: (2017) -
Cbl Enforces an SLP76-dependent Signaling Pathway for T Cell
Differentiation
por: Chiang, Y. Jeffrey, et al.
Publicado: (2009) -
Investigation of the Interaction between Cdc42 and Its Effector TOCA1: HANDOVER OF Cdc42 TO THE ACTIN REGULATOR N-WASP IS FACILITATED BY DIFFERENTIAL BINDING AFFINITIES
por: Watson, Joanna R., et al.
Publicado: (2016) -
The Immune Adaptor SLP-76 Binds to SUMO-RANGAP1 at Nuclear Pore Complex Filaments to Regulate Nuclear Import of Transcription Factors in T Cells
por: Liu, Hebin, et al.
Publicado: (2015)