Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach

Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. Over the past years, several studies have reported the association of missense mutations in the Hepatocyte Nuclear Factor 1 Alpha (HNF1A) with MODY3. Missense mutations in th...

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Detalles Bibliográficos
Autores principales: P., Sneha, D., Thirumal Kumar, C., George Priya Doss, R., Siva, Zayed, Hatem
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391926/
https://www.ncbi.nlm.nih.gov/pubmed/28410371
http://dx.doi.org/10.1371/journal.pone.0174953

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5391926/
https://www.ncbi.nlm.nih.gov/pubmed/28410371
http://dx.doi.org/10.1371/journal.pone.0174953

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