Cytosolic Hsp90α and its mitochondrial isoform Trap1 are differentially required in a breast cancer model

The Hsp90 family of molecular chaperones includes the cytosolic isoforms Hsp90a and Hsp90β and the mitochondrial isoform Trap1. Hsp90a/βsupport a large number of client proteins in the cytoplasm and the nucleus whereas Trap1 regulates oxidative phosphorylation in mitochondria. Many of the associated...

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Detalles Bibliográficos
Autores principales: Vartholomaiou, Evangelia, Madon-Simon, Marta, Hagmann, Stéphane, Mühlebach, Guillaume, Wurst, Wolfgang, Floss, Thomas, Picard, Didier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392260/
https://www.ncbi.nlm.nih.gov/pubmed/28407697
http://dx.doi.org/10.18632/oncotarget.15659

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392260/
https://www.ncbi.nlm.nih.gov/pubmed/28407697
http://dx.doi.org/10.18632/oncotarget.15659

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