SENP1 regulates PTEN stability to dictate prostate cancer development

SUMO protease SENP1 is elevated in multiple carcinomas including prostate cancer (PCa). SENP1 exhibits carcinogenic properties; it promotes androgen receptor-dependent and -independent cell proliferation, stabilizes HIF1a, increases VEGF, and supports angiogenesis. However, mice expressing an androg...

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Detalles Bibliográficos
Autores principales: Bawa-Khalfe, Tasneem, Yang, Feng-Ming, Ritho, Joan, Lin, Hui-Kuan, Cheng, Jinke, Yeh, Edward T.H.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392276/
https://www.ncbi.nlm.nih.gov/pubmed/27852060
http://dx.doi.org/10.18632/oncotarget.13283

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392276/
https://www.ncbi.nlm.nih.gov/pubmed/27852060
http://dx.doi.org/10.18632/oncotarget.13283

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