KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells

Emerging evidence indicates that dysregulation of microRNAs (miRNAs) contributes to hepatocellular carcinoma (HCC) tumorigenesis and development. Here, we found that miR-615-5p was obviously downregulated in HCC. Furthermore, the deficiency of demethylase KDM4B stimulated the CpG methylation of miR-...

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Detalles Bibliográficos
Autores principales: Chen, Zheng, Wang, Xiangling, Liu, Ruiyan, Chen, Lin, Yi, Jianying, Qi, Bing, Shuang, Zeyu, Liu, Min, Li, Xin, Li, Shengping, Tang, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392280/
https://www.ncbi.nlm.nih.gov/pubmed/27487123
http://dx.doi.org/10.18632/oncotarget.10832

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392280/
https://www.ncbi.nlm.nih.gov/pubmed/27487123
http://dx.doi.org/10.18632/oncotarget.10832

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