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KDM4B-mediated epigenetic silencing of miRNA-615-5p augments RAB24 to facilitate malignancy of hepatoma cells
Emerging evidence indicates that dysregulation of microRNAs (miRNAs) contributes to hepatocellular carcinoma (HCC) tumorigenesis and development. Here, we found that miR-615-5p was obviously downregulated in HCC. Furthermore, the deficiency of demethylase KDM4B stimulated the CpG methylation of miR-...
Autores principales: | Chen, Zheng, Wang, Xiangling, Liu, Ruiyan, Chen, Lin, Yi, Jianying, Qi, Bing, Shuang, Zeyu, Liu, Min, Li, Xin, Li, Shengping, Tang, Hua |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2016
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392280/ https://www.ncbi.nlm.nih.gov/pubmed/27487123 http://dx.doi.org/10.18632/oncotarget.10832 |
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