KRAS-dependent suppression of MYC enhances the sensitivity of cancer cells to cytotoxic agents

KRAS is the most commonly mutated oncogene, frequently associated with some of the deadliest forms of cancer. However, the need for potent and specific KRAS inhibitors remains unmet. Here, we evaluated the effects of selected cytotoxic agents on oncogenic KRAS signaling and drug response. The data p...

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Detalles Bibliográficos
Autores principales: Ischenko, Irene, Zhi, Jizu, Hayman, Michael J., Petrenko, Oleksi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392302/
https://www.ncbi.nlm.nih.gov/pubmed/28152508
http://dx.doi.org/10.18632/oncotarget.14929

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392302/
https://www.ncbi.nlm.nih.gov/pubmed/28152508
http://dx.doi.org/10.18632/oncotarget.14929

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