AFB1 hepatocarcinogenesis is via lipid peroxidation that inhibits DNA repair, sensitizes mutation susceptibility and induces aldehyde-DNA adducts at p53 mutational hotspot codon 249

Aflatoxin B1 (AFB1) contamination in the food chain is a major cause of hepatocellular carcinoma (HCC). More than 60% of AFB1 related HCC carry p53 codon 249 mutations but the causal mechanism remains unclear. We found that 1) AFB1 induces two types of DNA adducts in human hepatocytes, AFB1-8,9-epox...

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Detalles Bibliográficos
Autores principales: Weng, Mao-Wen, Lee, Hyun-Wook, Choi, Bongkun, Wang, Hsiang-Tsui, Hu, Yu, Mehta, Manju, Desai, Dhimant, Amin, Shantu, Zheng, Yi, Tang, Moon-Shong
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392321/
https://www.ncbi.nlm.nih.gov/pubmed/28212554
http://dx.doi.org/10.18632/oncotarget.15313

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392321/
https://www.ncbi.nlm.nih.gov/pubmed/28212554
http://dx.doi.org/10.18632/oncotarget.15313

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