Structural basis of PROTAC cooperative recognition for selective protein degradation

Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimaeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucida...

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Detalles Bibliográficos
Autores principales: Gadd, Morgan S., Testa, Andrea, Lucas, Xavier, Chan, Kwok-Ho, Chen, Wenzhang, Lamont, Douglas J., Zengerle, Michael, Ciulli, Alessio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392356/
https://www.ncbi.nlm.nih.gov/pubmed/28288108
http://dx.doi.org/10.1038/nchembio.2329

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392356/
https://www.ncbi.nlm.nih.gov/pubmed/28288108
http://dx.doi.org/10.1038/nchembio.2329

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