The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics

BACKGROUND: Malaria remains a problem for many countries classified as malaria free through cases imported from endemic regions. Imported cases to non-endemic countries often result in delays in diagnosis, are expensive to treat, and can sometimes cause secondary local transmission. The movement of...

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Autores principales: Tatem, Andrew J, Jia, Peng, Ordanovich, Dariya, Falkner, Michael, Huang, Zhuojie, Howes, Rosalind, Hay, Simon I, Gething, Peter W, Smith, David L
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science ;, The Lancet Pub. Group 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392593/
https://www.ncbi.nlm.nih.gov/pubmed/27777030
http://dx.doi.org/10.1016/S1473-3099(16)30326-7
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author Tatem, Andrew J
Jia, Peng
Ordanovich, Dariya
Falkner, Michael
Huang, Zhuojie
Howes, Rosalind
Hay, Simon I
Gething, Peter W
Smith, David L
author_facet Tatem, Andrew J
Jia, Peng
Ordanovich, Dariya
Falkner, Michael
Huang, Zhuojie
Howes, Rosalind
Hay, Simon I
Gething, Peter W
Smith, David L
author_sort Tatem, Andrew J
collection PubMed
description BACKGROUND: Malaria remains a problem for many countries classified as malaria free through cases imported from endemic regions. Imported cases to non-endemic countries often result in delays in diagnosis, are expensive to treat, and can sometimes cause secondary local transmission. The movement of malaria in endemic countries has also contributed to the spread of drug resistance and threatens long-term eradication goals. Here we focused on quantifying the international movements of malaria to improve our understanding of these phenomena and facilitate the design of mitigation strategies. METHODS: In this meta-analysis, we studied the database of publicly available nationally reported statistics on imported malaria in the past 10 years, covering more than 50 000 individual cases. We obtained data from 40 non-endemic countries and recorded the geographical variations. FINDINGS: Infection movements were strongly skewed towards a small number of high-traffic routes between 2005 and 2015, with the west Africa region accounting for 56% (13 947/24 941) of all imported cases to non-endemic countries with a reported travel destination, and France and the UK receiving the highest number of cases, with more than 4000 reported cases per year on average. Countries strongly linked by movements of imported cases are grouped by historical, language, and travel ties. There is strong spatial clustering of plasmodium species types. INTERPRETATION: The architecture of the air network, historical ties, demographics of travellers, and malaria endemicity contribute to highly heterogeneous patterns of numbers, routes, and species compositions of parasites transported. With global malaria eradication on the international agenda, malaria control altering local transmission, and the threat of drug resistance, understanding these patterns and their drivers is increasing in importance. FUNDING: Bill & Melinda Gates Foundation, National Institutes of Health, UK Medical Research Council, UK Department for International Development, Wellcome Trust.
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spelling pubmed-53925932017-04-25 The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics Tatem, Andrew J Jia, Peng Ordanovich, Dariya Falkner, Michael Huang, Zhuojie Howes, Rosalind Hay, Simon I Gething, Peter W Smith, David L Lancet Infect Dis Articles BACKGROUND: Malaria remains a problem for many countries classified as malaria free through cases imported from endemic regions. Imported cases to non-endemic countries often result in delays in diagnosis, are expensive to treat, and can sometimes cause secondary local transmission. The movement of malaria in endemic countries has also contributed to the spread of drug resistance and threatens long-term eradication goals. Here we focused on quantifying the international movements of malaria to improve our understanding of these phenomena and facilitate the design of mitigation strategies. METHODS: In this meta-analysis, we studied the database of publicly available nationally reported statistics on imported malaria in the past 10 years, covering more than 50 000 individual cases. We obtained data from 40 non-endemic countries and recorded the geographical variations. FINDINGS: Infection movements were strongly skewed towards a small number of high-traffic routes between 2005 and 2015, with the west Africa region accounting for 56% (13 947/24 941) of all imported cases to non-endemic countries with a reported travel destination, and France and the UK receiving the highest number of cases, with more than 4000 reported cases per year on average. Countries strongly linked by movements of imported cases are grouped by historical, language, and travel ties. There is strong spatial clustering of plasmodium species types. INTERPRETATION: The architecture of the air network, historical ties, demographics of travellers, and malaria endemicity contribute to highly heterogeneous patterns of numbers, routes, and species compositions of parasites transported. With global malaria eradication on the international agenda, malaria control altering local transmission, and the threat of drug resistance, understanding these patterns and their drivers is increasing in importance. FUNDING: Bill & Melinda Gates Foundation, National Institutes of Health, UK Medical Research Council, UK Department for International Development, Wellcome Trust. Elsevier Science ;, The Lancet Pub. Group 2017-01 /pmc/articles/PMC5392593/ /pubmed/27777030 http://dx.doi.org/10.1016/S1473-3099(16)30326-7 Text en © 2017 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY license http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Articles
Tatem, Andrew J
Jia, Peng
Ordanovich, Dariya
Falkner, Michael
Huang, Zhuojie
Howes, Rosalind
Hay, Simon I
Gething, Peter W
Smith, David L
The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title_full The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title_fullStr The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title_full_unstemmed The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title_short The geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
title_sort geography of imported malaria to non-endemic countries: a meta-analysis of nationally reported statistics
topic Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5392593/
https://www.ncbi.nlm.nih.gov/pubmed/27777030
http://dx.doi.org/10.1016/S1473-3099(16)30326-7
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