Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies...

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Detalles Bibliográficos
Autores principales: Wilcock, Donna M, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2004
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539292/
https://www.ncbi.nlm.nih.gov/pubmed/15588287
http://dx.doi.org/10.1186/1742-2094-1-24

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539292/
https://www.ncbi.nlm.nih.gov/pubmed/15588287
http://dx.doi.org/10.1186/1742-2094-1-24

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