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Passive immunotherapy against Aβ in aged APP-transgenic mice reverses cognitive deficits and depletes parenchymal amyloid deposits in spite of increased vascular amyloid and microhemorrhage

BACKGROUND: Anti-Aβ immunotherapy in transgenic mice reduces both diffuse and compact amyloid deposits, improves memory function and clears early-stage phospho-tau aggregates. As most Alzheimer disease cases occur well past midlife, the current study examined adoptive transfer of anti-Aβ antibodies...

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Detalles Bibliográficos
Autores principales:	Wilcock, Donna M, Rojiani, Amyn, Rosenthal, Arnon, Subbarao, Sangeetha, Freeman, Melissa J, Gordon, Marcia N, Morgan, Dave
Formato:	Texto
Lenguaje:	English
Publicado:	BioMed Central 2004
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC539292/ https://www.ncbi.nlm.nih.gov/pubmed/15588287 http://dx.doi.org/10.1186/1742-2094-1-24

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