SMRT genome assembly corrects reference errors, resolving the genetic basis of virulence in Mycobacterium tuberculosis

BACKGROUND: The genetic basis of virulence in Mycobacterium tuberculosis has been investigated through genome comparisons of virulent (H37Rv) and attenuated (H37Ra) sister strains. Such analysis, however, relies heavily on the accuracy of the sequences. While the H37Rv reference genome has had sever...

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Detalles Bibliográficos
Autores principales: Elghraoui, Afif, Modlin, Samuel J., Valafar, Faramarz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393005/
https://www.ncbi.nlm.nih.gov/pubmed/28415976
http://dx.doi.org/10.1186/s12864-017-3687-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393005/
https://www.ncbi.nlm.nih.gov/pubmed/28415976
http://dx.doi.org/10.1186/s12864-017-3687-5

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