Cargando…

Discovery and characterization of natural tropolones as inhibitors of the antibacterial target CapF from Staphylococcus aureus

The rapid spread of antibiotic-resistance among pathogenic bacteria poses a serious risk for public health. The search for novel therapeutic strategies and antimicrobial compounds is needed to ameliorate this menace. The bifunctional metalloenzyme CapF is an antibacterial target produced by certain...

Descripción completa

Detalles Bibliográficos
Autores principales:	Nakano, Koichiro, Chigira, Takeru, Miyafusa, Takamitsu, Nagatoishi, Satoru, Caaveiro, Jose M. M., Tsumoto, Kouhei
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393024/ https://www.ncbi.nlm.nih.gov/pubmed/26471247 http://dx.doi.org/10.1038/srep15337

Ejemplares similares

Crystal structure of the capsular polysaccharide synthesizing protein CapE of Staphylococcus aureus
por: Miyafusa, Takamitsu, et al.
Publicado: (2013)

Disruption of cell adhesion by an antibody targeting the cell-adhesive intermediate (X-dimer) of human P-cadherin
por: Kudo, Shota, et al.
Publicado: (2017)

Structure and role of the linker domain of the iron surface-determinant protein IsdH in heme transportation in Staphylococcus aureus
por: Valenciano-Bellido, Sandra, et al.
Publicado: (2022)

Discovery of chemical probes that suppress Wnt/β‐catenin signaling through high‐throughput screening
por: Yamaguchi, Kiyoshi, et al.
Publicado: (2020)

Modulation of a conformational ensemble by a small molecule that inhibits key protein–protein interactions involved in cell adhesion
por: Senoo, Akinobu, et al.
Publicado: (2023)

Validation of the Center of Applied Psychology Female Sexuality Questionnaire (CAPFS-Q)
por: Tirado-González, Sonia, et al.
Publicado: (2021)

Targeting hemoglobin receptors IsdH and IsdB of Staphylococcus aureus with a single VHH antibody inhibits bacterial growth
por: Valenciano-Bellido, Sandra, et al.
Publicado: (2023)

Affinity Improvement of a Therapeutic Antibody by Structure-Based Computational Design: Generation of Electrostatic Interactions in the Transition State Stabilizes the Antibody-Antigen Complex
por: Kiyoshi, Masato, et al.
Publicado: (2014)

Mechanism of dimerization and structural features of human LI-cadherin
por: Yui, Anna, et al.
Publicado: (2021)

Anti-InlA single-domain antibodies that inhibit the cell invasion of Listeria monocytogenes
por: Yamazaki, Taichi, et al.
Publicado: (2023)

Thermodynamic and computational analyses reveal the functional roles of the galloyl group of tea catechins in molecular recognition
por: Takahashi, Tomoya, et al.
Publicado: (2018)

Raman Spectroscopic Analysis of Highly-Concentrated Antibodies under the Acid-Treated Conditions
por: Sato, Yusui, et al.
Publicado: (2023)

Biosynthesis of Antibacterial Iron-Chelating Tropolones in Aspergillus nidulans as Response to Glycopeptide-Producing Streptomycetes
por: Gerke, Jennifer, et al.
Publicado: (2022)

5-(Phenyldiazenyl)tropolone
por: Hill, Tania N., et al.
Publicado: (2012)

Stereochemical and Biosynthetic Rationalisation of the Tropolone Sesquiterpenoids
por: Li, Lei, et al.
Publicado: (2022)

Molecular basis for governing the morphology of type-I collagen fibrils by Osteomodulin
por: Tashima, Takumi, et al.
Publicado: (2018)

PRDM14 directly interacts with heat shock proteins HSP90α and glucose‐regulated protein 78
por: Moriya, Chiharu, et al.
Publicado: (2017)

Conformational features and interaction mechanisms of V(H)H antibodies with β‐hairpin CDR3: A case of Nb8‐HigB2 interaction
por: Yamamoto, Koichi, et al.
Publicado: (2023)

Exploring designability of electrostatic complementarity at an antigen-antibody interface directed by mutagenesis, biophysical analysis, and molecular dynamics simulations
por: Yoshida, Kouhei, et al.
Publicado: (2019)

Molecular mechanism underlying the increased risk of colorectal cancer metastasis caused by single nucleotide polymorphisms in LI-cadherin gene
por: Yui, Anna, et al.
Publicado: (2023)

Synthetic Biology Driven Biosynthesis of Unnatural Tropolone Sesquiterpenoids
por: Schotte, Carsten, et al.
Publicado: (2020)

Rapid Heme Transfer Reactions between NEAr Transporter Domains of Staphylococcus aureus: A Theoretical Study Using QM/MM and MD Simulations
por: Moriwaki, Yoshitaka, et al.
Publicado: (2015)

Proteomic identification and validation of novel interactions of the putative tumor suppressor PRELP with membrane proteins including IGFI-R and p75NTR
por: Kosuge, Hirofumi, et al.
Publicado: (2021)

Biophysical Characterization of the Contribution of the Fab Region to the IgG-FcγRIIIa Interaction
por: Kosuge, Hirofumi, et al.
Publicado: (2022)

Structural and thermodynamical insights into the binding and inhibition of FIH-1 by the N-terminal disordered region of Mint3
por: Ten, Tensho, et al.
Publicado: (2021)

A glutamine sensor that directly activates TORC1
por: Tanigawa, Mirai, et al.
Publicado: (2021)

Non-enzymatic pyridine ring formation in the biosynthesis of the rubrolone tropolone alkaloids
por: Yan, Yijun, et al.
Publicado: (2016)

Crystal and molecular structures of fac-[Re(Bid)(PPh(3))(CO)(3)] [Bid is tropolone (TropH) and tribromotropolone (TropBr(3)H)]
por: Schutte-Smith, Marietjie, et al.
Publicado: (2022)

Regulation of cadherin dimerization by chemical fragments as a trigger to inhibit cell adhesion
por: Senoo, Akinobu, et al.
Publicado: (2021)

Structural basis for inhibition of the Tob-CNOT7 interaction by a fragment screening approach
por: Bai, Yuwei, et al.
Publicado: (2015)

Through-bond effects in the ternary complexes of thrombin sandwiched by two DNA aptamers
por: Pica, Andrea, et al.
Publicado: (2017)

capB2 Expression Is Associated with Staphylococcus aureus Pathogenicity
por: Li, Dan, et al.
Publicado: (2017)

Assessing the Heterogeneity of the Fc-Glycan of a Therapeutic Antibody Using an engineered FcγReceptor IIIa-Immobilized Column
por: Kiyoshi, Masato, et al.
Publicado: (2018)

Structural basis for self-assembly of a cytolytic pore lined by protein and lipid
por: Tanaka, Koji, et al.
Publicado: (2015)

Molecular basis for thermal stability and affinity in a VHH: Contribution of the framework region and its influence in the conformation of the CDR3
por: Kinoshita, Seisho, et al.
Publicado: (2022)

Antibacterial mechanism of fraxetin against Staphylococcus aureus
por: WANG, HAITING, et al.
Publicado: (2014)

Highly sensitive HPLC analysis and biophysical characterization of N‐glycans of IgG‐Fc domain in comparison between CHO and 293 cells using FcγRIIIa ligand
por: Kosuge, Hirofumi, et al.
Publicado: (2020)

Discovery of a novel antibacterial protein CB6-C to target methicillin-resistant Staphylococcus aureus
por: Zhang, Haipeng, et al.
Publicado: (2022)

New Family Members of FG Repeat Proteins and Their Unexplored Roles During Phase Separation
por: Shinkai, Yoichi, et al.
Publicado: (2021)

Structural basis for selective inhibition of human serine hydroxymethyltransferase by secondary bile acid conjugate
por: Ota, Tomoki, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_t8f01ogol3jcq86ra44n93fldd