The DDR at telomeres lacking intact shelterin does not require substantial chromatin decompaction

Telomeres are protected by shelterin, a six-subunit protein complex that represses the DNA damage response (DDR) at chromosome ends. Extensive data suggest that TRF2 in shelterin remodels telomeres into the t-loop structure, thereby hiding telomere ends from double-stranded break repair and ATM sign...

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Detalles Bibliográficos
Autores principales: Timashev, Leonid A., Babcock, Hazen, Zhuang, Xiaowei, de Lange, Titia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393053/
https://www.ncbi.nlm.nih.gov/pubmed/28381412
http://dx.doi.org/10.1101/gad.294108.116

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393053/
https://www.ncbi.nlm.nih.gov/pubmed/28381412
http://dx.doi.org/10.1101/gad.294108.116

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