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Asc1, Hel2, and Slh1 couple translation arrest to nascent chain degradation

Premature arrest of protein synthesis within the open reading frame elicits a protective response that degrades the incomplete nascent chain. In this response, arrested 80S ribosomes are split into their large and small subunits, allowing assembly of the ribosome quality control complex (RQC), which...

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Detalles Bibliográficos
Autores principales: Sitron, Cole S., Park, Joseph H., Brandman, Onn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cold Spring Harbor Laboratory Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393187/
https://www.ncbi.nlm.nih.gov/pubmed/28223409
http://dx.doi.org/10.1261/rna.060897.117