TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells

In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation of TGFβ activation leads to elevated expression and...

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Detalles Bibliográficos
Autores principales: Bailey, Katie L., Agarwal, Ekta, Chowdhury, Sanjib, Luo, Jiangtao, Brattain, Michael G., Black, Jennifer D., Wang, Jing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393866/
https://www.ncbi.nlm.nih.gov/pubmed/28414818
http://dx.doi.org/10.1371/journal.pone.0176096

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393866/
https://www.ncbi.nlm.nih.gov/pubmed/28414818
http://dx.doi.org/10.1371/journal.pone.0176096

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