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TGFβ/Smad3 regulates proliferation and apoptosis through IRS-1 inhibition in colon cancer cells
In this study, we have uncovered a novel crosstalk between TGFβ and IGF-1R signaling pathways. We show for the first time that expression and activation of IRS-1, an IGF-1R adaptor protein, is decreased by TGFβ/Smad3 signaling. Loss or attenuation of TGFβ activation leads to elevated expression and...
| Autores principales: | , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Public Library of Science
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393866/ https://www.ncbi.nlm.nih.gov/pubmed/28414818 http://dx.doi.org/10.1371/journal.pone.0176096 |