BIG1 is required for the survival of deep layer neurons, neuronal polarity, and the formation of axonal tracts between the thalamus and neocortex in developing brain

BIG1, an activator protein of the small GTPase, Arf, and encoded by the Arfgef1 gene, is one of candidate genes for epileptic encephalopathy. To know the involvement of BIG1 in epileptic encephalopathy, we analyzed BIG1-deficient mice and found that BIG1 regulates neurite outgrowth and brain develop...

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Detalles Bibliográficos
Autores principales: Teoh, Jia-Jie, Iwano, Tomohiko, Kunii, Masataka, Atik, Nur, Avriyanti, Erda, Yoshimura, Shin-ichiro, Moriwaki, Kenta, Harada, Akihiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393877/
https://www.ncbi.nlm.nih.gov/pubmed/28414797
http://dx.doi.org/10.1371/journal.pone.0175888

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393877/
https://www.ncbi.nlm.nih.gov/pubmed/28414797
http://dx.doi.org/10.1371/journal.pone.0175888

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