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Transient chromatin properties revealed by polymer models and stochastic simulations constructed from Chromosomal Capture data

Chromatin organization can be probed by Chromosomal Capture (5C) data, from which the encounter probability (EP) between genomic sites is presented in a large matrix. This matrix is averaged over a large cell population, revealing diagonal blocks called Topological Associating Domains (TADs) that re...

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Detalles Bibliográficos
Autores principales: Shukron, Ofir, Holcman, David
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5393903/
https://www.ncbi.nlm.nih.gov/pubmed/28369076
http://dx.doi.org/10.1371/journal.pcbi.1005469