Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove

Antigen processing on MHCI involves the exchange of low-affinity peptides by high-affinity, immunodominant ones. This peptide editing process is mediated by tapasin and ERAAP at the peptide C- and N-terminus, respectively. Since tapasin does not contact the peptide directly, a sensing mechanism invo...

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Detalles Bibliográficos
Autores principales: Fisette, Olivier, Wingbermühle, Sebastian, Schäfer, Lars V.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394104/
https://www.ncbi.nlm.nih.gov/pubmed/28458665
http://dx.doi.org/10.3389/fimmu.2017.00408

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394104/
https://www.ncbi.nlm.nih.gov/pubmed/28458665
http://dx.doi.org/10.3389/fimmu.2017.00408

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