Cargando…

Partial Dissociation of Truncated Peptides Influences the Structural Dynamics of the MHCI Binding Groove

Antigen processing on MHCI involves the exchange of low-affinity peptides by high-affinity, immunodominant ones. This peptide editing process is mediated by tapasin and ERAAP at the peptide C- and N-terminus, respectively. Since tapasin does not contact the peptide directly, a sensing mechanism invo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Fisette, Olivier, Wingbermühle, Sebastian, Schäfer, Lars V.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394104/ https://www.ncbi.nlm.nih.gov/pubmed/28458665 http://dx.doi.org/10.3389/fimmu.2017.00408

Ejemplares similares

Partial peptide dissociation and binding groove plasticity in two major histocompatibility complex class I alleles – differences between alleles versus force field and sampling effects
por: Wingbermühle, Sebastian, et al.
Publicado: (2022)

Molecular mechanism of peptide editing in the tapasin–MHC I complex
por: Fisette, Olivier, et al.
Publicado: (2016)

Individual MHCI-Restricted T-Cell Receptors are Characterized by a Unique Peptide Recognition Signature
por: Wooldridge, Linda
Publicado: (2013)

Toxoplasma gondii peptide ligands open the gate of the HLA class I binding groove
por: McMurtrey, Curtis, et al.
Publicado: (2016)

DeepMHCI: an anchor position-aware deep interaction model for accurate MHC-I peptide binding affinity prediction
por: Qu, Wei, et al.
Publicado: (2023)

High-Throughput, Quantitative Analysis of Peptide-Exchanged MHCI Complexes by Native Mass Spectrometry
por: Schachner, Luis F., et al.
Publicado: (2022)

Distortion of the Major Histocompatibility Complex Class I Binding Groove to Accommodate an Insulin-derived 10-Mer Peptide
por: Motozono, Chihiro, et al.
Publicado: (2015)

HLA-DM catalytically enhances peptide dissociation by sensing peptide–MHC class II interactions throughout the peptide-binding cleft
por: Reyes-Vargas, Eduardo, et al.
Publicado: (2020)

Association of MHCY genotypes in lines of chickens divergently selected for high or low antibody response to sheep red blood cells
por: Zhang, Jibin, et al.
Publicado: (2021)

The partial dissociation of MHC class I–bound peptides exposes their N terminus to trimming by endoplasmic reticulum aminopeptidase 1
por: Papakyriakou, Athanasios, et al.
Publicado: (2018)

High-affinity CD8 variants enhance the sensitivity of pMHCI antigen recognition via low-affinity TCRs
por: Knezevic, Lea, et al.
Publicado: (2023)

Cryptic protein-protein interaction motifs in the cytoplasmic domain of MHCI proteins
por: Frietze, Karla K., et al.
Publicado: (2016)

The fowl adenovirus serotype 4 (FAdV-4) induce cellular pathway in chickens to produce interferon and antigen-presented molecules (MHCI/II)
por: Li, Meizhen, et al.
Publicado: (2021)

Viral MHCI inhibition evades tissue-resident memory T cell formation and responses
por: Lauron, Elvin J., et al.
Publicado: (2019)

Progranulin mediates immune evasion of pancreatic ductal adenocarcinoma through regulation of MHCI expression
por: Cheung, Phyllis F., et al.
Publicado: (2022)

Research Note: MHCY haplotype impacts Campylobacter jejuni colonization in a backcross [(Line 6(1) x Line N) x Line N] population
por: Zhang, Jibin, et al.
Publicado: (2021)

Human OGA binds substrates in a conserved peptide recognition groove
por: Schimpl, Marianne, et al.
Publicado: (2010)

AT-hook peptides bind the major and minor groove of AT-rich DNA duplexes
por: Garabedian, Alyssa, et al.
Publicado: (2022)

CD8(+) T-cell specificity is compromised at a defined MHCI/CD8 affinity threshold
por: Dockree, Tamsin, et al.
Publicado: (2017)

Identification of human viral protein-derived ligands recognized by individual MHCI-restricted T-cell receptors
por: Szomolay, Barbara, et al.
Publicado: (2016)

Heterogeneous dissociation process of truncated RNAs by oligomerized Vasa helicase
por: Kinoshita, Yoshimi, et al.
Publicado: (2021)

Dissociation of minor groove binders from DNA: insights from metadynamics simulations
por: Vargiu, Attilio Vittorio, et al.
Publicado: (2008)

Rapid identification of bovine MHCI haplotypes in genetically divergent cattle populations using next-generation sequencing
por: Vasoya, Deepali, et al.
Publicado: (2016)

Zooming into the binding groove of HLA molecules: which positions and which substitutions change peptide binding most?
por: van Deutekom, Hanneke W. M., et al.
Publicado: (2015)

Iterative Conversion of Cyclin Binding Groove Peptides into Druglike CDK Inhibitors with Antitumor Activity
por: Premnath, Padmavathy Nandha, et al.
Publicado: (2014)

Peptide Based Inhibitors of Protein Binding to the Mitogen-Activated Protein Kinase Docking Groove
por: Alexa, Anita, et al.
Publicado: (2021)

The Culture Dish Surface Influences the Phenotype and Dissociation Strategy in Distinct Mouse Macrophage Populations
por: Song, Qiaoling, et al.
Publicado: (2022)

Peptidomes and Structures Illustrate How SLA-I Micropolymorphism Influences the Preference of Binding Peptide Length
por: Wei, Xiaohui, et al.
Publicado: (2022)

HIV chromatin is a preferred target for drugs that bind in the DNA minor groove
por: Collings, Clayton K., et al.
Publicado: (2019)

Folding of Truncated Granulin Peptides
por: Takjoo, Rozita, et al.
Publicado: (2020)

Assembly of the MHC I peptide-loading complex determined by a conserved ionic lock-switch
por: Blees, Andreas, et al.
Publicado: (2015)

TAPBPR mediates peptide dissociation from MHC class I using a leucine lever
por: Ilca, F Tudor, et al.
Publicado: (2018)

The strength of selection is consistent across both domains of the MHC class I peptide-binding groove in birds
por: Minias, Piotr, et al.
Publicado: (2021)

Development of antidrug antibodies against adalimumab maps to variation within the HLA-DR peptide-binding groove
por: Tsakok, Teresa, et al.
Publicado: (2023)

Interaction of Nevirapine with the Peptide Binding Groove of HLA-DRB1*01:01 and Its Effect on the Conformation of HLA-Peptide Complex
por: Hirasawa, Makoto, et al.
Publicado: (2018)

Integrin triplets of marine sponges in the murine and human MHCI-CD8 interface and in the interface of human neural receptor heteromers and subunits
por: Tarakanov, Alexander O, et al.
Publicado: (2013)

Prediction of Specific TCR-Peptide Binding From Large Dictionaries of TCR-Peptide Pairs
por: Springer, Ido, et al.
Publicado: (2020)

Mg(2+) in the Major Groove Modulates B-DNA Structure and Dynamics
por: Guéroult, Marc, et al.
Publicado: (2012)

Sustained Release of Minor-Groove-Binding Antibiotic Netropsin from Calcium-Coated Groove-Rich DNA Particles
por: Jeon, Hyunsu, et al.
Publicado: (2019)

On TCR binding predictors failing to generalize to unseen peptides
por: Grazioli, Filippo, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_p6b22ff4ecl1hfstv2ecfdscmh