Inhibition of Mitochondrial p53 Accumulation by PFT-μ Prevents Cisplatin-Induced Peripheral Neuropathy

Chemotherapy-induced peripheral neuropathy (CIPN), a debilitating major side effect of cancer treatment, is characterized by pain and sensory loss in hand and feet. Platinum-based chemotherapeutics like cisplatin frequently induce CIPN. The molecular mechanism underlying these neurotoxic symptoms is...

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Detalles Bibliográficos
Autores principales: Maj, Magdalena A., Ma, Jiacheng, Krukowski, Karen N., Kavelaars, Annemieke, Heijnen, Cobi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394177/
https://www.ncbi.nlm.nih.gov/pubmed/28458631
http://dx.doi.org/10.3389/fnmol.2017.00108

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5394177/
https://www.ncbi.nlm.nih.gov/pubmed/28458631
http://dx.doi.org/10.3389/fnmol.2017.00108

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